This work is licensed under a Creative Commons Attribution 4.0 International License.
HEXIM1 (147-164), BR
General Information
DRACP ID DRACP01934
Peptide Name HEXIM1 (147-164), BR
Sequence QLGKKKHRRRPSKKKRHW
Sequence Length 18
UniProt ID O94992
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | 5%Killing=100 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HaCat: Not active up to 100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C104H180N42O21
Absent amino acids ACDEFIMNTVY
Common amino acids K
Mass 265823
Pl 13
Basic residues 12
Acidic residues 0
Hydrophobic residues 2
Net charge 12
Boman Index -10305
Hydrophobicity -284.44
Aliphatic Index 21.67
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 323.53
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12674
This work is licensed under a Creative Commons Attribution 4.0 International License.