This work is licensed under a Creative Commons Attribution 4.0 International License.
HEXIM1 (147-164)[K4,5,6,13,14,15R], BR-RRR12
General Information
DRACP ID DRACP01935
Peptide Name HEXIM1 (147-164)[K4,5,6,13,14,15R], BR-RRR12
Sequence QLGRRRHRRRPSRRRRHW
Sequence Length 18
UniProt ID O94992
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | 25%Killing=100 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HaCat: Not active up to 100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C104H180N54O21
Absent amino acids ACDEFIKMNTVY
Common amino acids R
Mass 282629
Pl 13.45
Basic residues 12
Acidic residues 0
Hydrophobic residues 2
Net charge 12
Boman Index -15927
Hydrophobicity -304.44
Aliphatic Index 21.67
Half Life
Mammalian: 0.8 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 323.53
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12675
This work is licensed under a Creative Commons Attribution 4.0 International License.