This work is licensed under a Creative Commons Attribution 4.0 International License.
LTV-HEXIM1 (147-164)[K4,5,6,13,14,15R], LTV-BR (RRR12)
General Information
DRACP ID DRACP01939
Peptide Name LTV-HEXIM1 (147-164)[K4,5,6,13,14,15R], LTV-BR (RRR12)
Sequence LTVSPWYGCGQLGRRRHRRRPSRRRRHW
Sequence Length 28
UniProt ID O94992
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | 78%Killing=10 µM; 100%Killing=50 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C154H249N65O34S
Absent amino acids ADEFIKMN
Common amino acids R
Mass 406888
Pl 12.87
Basic residues 12
Acidic residues 0
Hydrophobic residues 5
Net charge 12
Boman Index -15093
Hydrophobicity -180
Aliphatic Index 38.21
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 12490
Absorbance 280nm 462.59
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12681
This work is licensed under a Creative Commons Attribution 4.0 International License.