This work is licensed under a Creative Commons Attribution 4.0 International License.
LTV-PAP, LTV-KLA
General Information
DRACP ID DRACP01942
Peptide Name LTV-PAP, LTV-KLA
Sequence LTVSPWYGCGKLAKLAKKLAKLAK
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| OPM-2 | Plasma cell myeloma; Multiple myeloma | Carcinoma | 78%Killing=10 µM; 100%Killing=50 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO-K1: 100%Killing=50 µM; HFF: 80%Killing=50 µM; WI-38: 55%Killing=50 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H207N31O28S
Absent amino acids DEFHIMNQR
Common amino acids K
Mass 299869
Pl 10.85
Basic residues 6
Acidic residues 0
Hydrophobic residues 11
Net charge 6
Boman Index 196
Hydrophobicity 14.17
Aliphatic Index 110
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 6990
Absorbance 280nm 303.91
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12684
This work is licensed under a Creative Commons Attribution 4.0 International License.