3

General Information


DRACP ID  DRACP01947

Peptide Name   3

Sequence  GLKDPLKSVAKHLVK

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma EC50>100 μM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01947

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C75H133N21O19

Absent amino acids  CEFIMNQRTWY

Common amino acids  K

Mass  188292

Pl  10.8

Basic residues  5

Acidic residues  1

Hydrophobic residues  6

Net charge  4

Boman Index  -1339

Hydrophobicity  -23.33

Aliphatic Index  123.33

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30953170

Title  De novo design of anticancer peptides by ensemble artificial neural networks

Doi 10.1007/s00894-019-4007-6

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13111

DRACP is developed by Dr.Zheng's team.