TsAP-1 [S7K][G10K][G11K][S12I][S14K]

General Information


DRACP ID  DRACP01963

Peptide Name   TsAP-1 [S7K][G10K][G11K][S12I][S14K]

Sequence  FLSLIPKLVKKIIKAFK

Sequence Length  17

UniProt ID  S6CWV8 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
U-251MG Astrocytoma Carcinoma IC50=2.9 µM MTT assay 24 h 1

Hemolytic Activity  Horse erythrocytes: 28% Hemolysis=5 µM; Horse erythrocytes: 100% Hemolysis=20 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01963

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C100H172N22O19

Absent amino acids  CDEGHMNQRTWY

Common amino acids  K

Mass  227218

Pl  11.4

Basic residues  5

Acidic residues  0

Hydrophobic residues  10

Net charge  5

Boman Index  1018

Hydrophobicity  85.88

Aliphatic Index  160.59

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23770440

Title  Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities

Doi 10.1016/j.biochi.2013.06.003

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




CancerPPD ID  3130

DBAASP ID  DBAASPS_4299

DRACP is developed by Dr.Zheng's team.