This work is licensed under a Creative Commons Attribution 4.0 International License.
TsAP-2 [G7K][G10K][G11K][S14K]
General Information
DRACP ID DRACP01964
Peptide Name TsAP-2 [G7K][G10K][G11K][S14K]
Sequence FLGMIPKLIKKLIKAFK
Sequence Length 17
UniProt ID S6D3A7
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-251MG | Astrocytoma | Carcinoma | IC50=2.0 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Horse erythrocytes: 28% Hemolysis=5 µM; Horse erythrocytes: 100% Hemolysis=20 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C99H170N22O18S
Absent amino acids CDEHNQRSTVWY
Common amino acids K
Mass 227422
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 9
Net charge 5
Boman Index 1283
Hydrophobicity 74.71
Aliphatic Index 143.53
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23770440
Title Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities
Doi 10.1016/j.biochi.2013.06.003
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4300
This work is licensed under a Creative Commons Attribution 4.0 International License.