Temporin-CPb

General Information


DRACP ID  DRACP01965

Peptide Name   Temporin-CPb

Sequence  FLPIVGRLISGIL

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Lithobates capito

Type  Native peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma LC50>80 µM MTS assay Not available 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis>100 µM

Normal (non-cancerous) Cytotoxicity  HaCat: LC50>200 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01965

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C68H116N16O15

Absent amino acids  ACDEHKMNQTWY

Common amino acids  IL

Mass  161200

Pl  10.55

Basic residues  1

Acidic residues  0

Hydrophobic residues  8

Net charge  1

Boman Index  2010

Hydrophobicity  186.15

Aliphatic Index  202.31

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29842923

Title  Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins

Doi 10.1016/j.peptides.2018.05.011

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_13347

DRACP is developed by Dr.Zheng's team.