This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1SPa
General Information
DRACP ID DRACP01968
Peptide Name Temporin-1SPa
Sequence FLSAITSILGKFF
Sequence Length 13
UniProt ID P0DQK5
PubChem CID Not available
Origin Rana septentrionalis
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50>80 µM | MTS assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=37.5 µM
Normal (non-cancerous) Cytotoxicity HaCat: LC50=200 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C72H110N14O17
Absent amino acids CDEHMNPQRVWY
Common amino acids F
Mass 165797
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 8
Net charge 1
Boman Index 1645
Hydrophobicity 155.38
Aliphatic Index 127.69
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29842923
Title Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins
Doi 10.1016/j.peptides.2018.05.011
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_13350
This work is licensed under a Creative Commons Attribution 4.0 International License.