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Magainin-2 [G3K; K4,10,11,14Dap; F5W; A15K; G18Dap; E19Dap; M21Nle]
General Information
DRACP ID DRACP01972
Peptide Name Magainin-2 [G3K; K4,10,11,14Dap; F5W; A15K; G18Dap; E19Dap; M21Nle]
Sequence GIKXWLHSAXXFGXKFVXXIXNS
Sequence Length 23
UniProt ID P11006
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | EC50=55±1.8 µM(pH=7.4) | WST-1 assay | 24 h | 1 |
Hemolytic Activity Human kidney-derived GM cells: EC50= 19.8±0.3 µM(pH=6); EC50>100 µM(pH=7.4)
Normal (non-cancerous) Cytotoxicity HEK293: EC50>100 µM(pH=7.4)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(4/10/11/14/18/19)=Dap; X(21)=Nle
Chiral L
Physicochemical Information
Formula C87H116N22O13
Absent amino acids CDEMPQRTY
Common amino acids X
Mass 284060
Pl 10.81
Basic residues 3
Acidic residues 0
Hydrophobic residues 8
Net charge 3
Boman Index 158
Hydrophobicity 28.7
Aliphatic Index 67.83
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31161686
Title Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13421
This work is licensed under a Creative Commons Attribution 4.0 International License.