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Magainin-2 [G3,18Dap; K4,10,11,14Dap; F5W; A15Dap; E19Dap; M21Nle]
General Information
DRACP ID DRACP01973
Peptide Name Magainin-2 [G3,18Dap; K4,10,11,14Dap; F5W; A15Dap; E19Dap; M21Nle]
Sequence GIXXWLHSAXXFGXXFVXXIXNS
Sequence Length 23
UniProt ID P11006
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | EC50=61.4±1.7 µM(pH=7.4) | WST-1 assay | 24 h | 1 |
Hemolytic Activity Human kidney-derived GM cells: EC50=7.6±2.1 µM(pH=6); EC50=25.6±4.5 µM(pH=7.4)
Normal (non-cancerous) Cytotoxicity HEK293: EC50=15.7±1.8 µM(pH=7.4)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(3/4/10/11/14/15/18/19)=Dap; X(21)=Nle
Chiral L
Physicochemical Information
Formula C75H88N18O9
Absent amino acids CDEKMPQRTY
Common amino acids X
Mass 276822
Pl 7.55
Basic residues 1
Acidic residues 0
Hydrophobic residues 8
Net charge 1
Boman Index 1268
Hydrophobicity 62.61
Aliphatic Index 67.83
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31161686
Title Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13422
This work is licensed under a Creative Commons Attribution 4.0 International License.