Peptide Libraray

B1CTcu5 (Linear Brevinin CTcu5)

General Information

DRACP ID DRACP01974

Peptide Name B1CTcu5 (Linear Brevinin CTcu5)

Sequence LIAGLAANFLPQILCKIARKC

Sequence Length 21

UniProt ID E3SYG2 D2K8D1 C3RTH8

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A431	Skin squamous cell carcinoma	Carcinoma	50% Cytotoxicity>100 µg/ml	MTT assay	Not available	1

Hemolytic Activity Human erythrocytes: 37% Hemolysis=200 µM

Normal (non-cancerous) Cytotoxicity HEK293: 50%Cytotoxicity>100 µg/ml; PBMC: 50%Cytotoxicity=75.1±1.46 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP01974

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C103H178N28O24S2

Absent amino acids DEHMSTVWY

Common amino acids AL

Mass 261380

Pl 9.76

Basic residues 3

Acidic residues 0

Hydrophobic residues 12

Net charge 3

Boman Index 996

Hydrophobicity 106.67

Aliphatic Index 149.05

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 6.25

Polar residues 4

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25997127

Title Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides

Doi 10.1371/journal.pone.0124210

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_13651