This work is licensed under a Creative Commons Attribution 4.0 International License.
B1CTcu5-LIAG
General Information
DRACP ID DRACP01975
Peptide Name B1CTcu5-LIAG
Sequence LAANFLPQILCKIARKC
Sequence Length 17
UniProt ID E3SYG2 D2K8D1 C3RTH8
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A431 | Skin squamous cell carcinoma | Carcinoma | 50% Cytotoxicity>100 µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 30% Hemolysis=200 µM
Normal (non-cancerous) Cytotoxicity HEK293: 50%Cytotoxicity>100 µg/ml; PBMC: 50%Cytotoxicity>100 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys11<--->Cys17
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C86H148N24O20S2
Absent amino acids DEGHMSTVWY
Common amino acids AL
Mass 218799
Pl 9.76
Basic residues 3
Acidic residues 0
Hydrophobic residues 9
Net charge 3
Boman Index -263
Hydrophobicity 74.71
Aliphatic Index 132.35
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 7.81
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25997127
Title Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides
Doi 10.1371/journal.pone.0124210
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13655
This work is licensed under a Creative Commons Attribution 4.0 International License.