B1CTcu5K

General Information


DRACP ID  DRACP01976

Peptide Name   B1CTcu5K

Sequence  KIAGLAANFLPQILCKIARKC

Sequence Length  21

UniProt ID  E3SYG2  D2K8D1  C3RTH8 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A431 Skin squamous cell carcinoma Carcinoma 50% Cytotoxicity>100 µg/ml MTT assay Not available 1

Hemolytic Activity  Human erythrocytes: 15% Hemolysis=200 µM

Normal (non-cancerous) Cytotoxicity  HEK293: 50%Cytotoxicity>100 µg/ml; PBMC: 50%Cytotoxicity=74.5±2.44 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01976

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys15<--->Cys21

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C103H179N29O24S2

Absent amino acids  DEHMSTVWY

Common amino acids  A

Mass  262881

Pl  10.51

Basic residues  4

Acidic residues  0

Hydrophobic residues  11

Net charge  4

Boman Index  -51

Hydrophobicity  70

Aliphatic Index  130.48

Half Life 
  Mammalian: 5.5 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  6.25

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25997127

Title  Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides

Doi 10.1371/journal.pone.0124210

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13656

DRACP is developed by Dr.Zheng's team.