This work is licensed under a Creative Commons Attribution 4.0 International License.
B1CTcu5D
General Information
DRACP ID DRACP01980
Peptide Name B1CTcu5D
Sequence liaglaanflpqilckiarkc
Sequence Length 21
UniProt ID E3SYG2 D2K8D1 C3RTH8
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A431 | Skin squamous cell carcinoma | Carcinoma | 50% Cytotoxicity>100 µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 40.22% Hemolysis=200 µg/ml
Normal (non-cancerous) Cytotoxicity HEK293: 50%Cytotoxicity>100 µg/ml; PBMC: 50%Cytotoxicity=71.4±2.3 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys15<--->Cys21
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral D
Physicochemical Information
Formula H-40O-20
Absent amino acids ACDEFGHIKLMNPQRSTVWY
Common amino acids ACDEFGHIKLMNPQRSTVWYX
Mass -342
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 0
Net charge 0
Boman Index 0
Hydrophobicity 0
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25997127
Title Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides
Doi 10.1371/journal.pone.0124210
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13667
This work is licensed under a Creative Commons Attribution 4.0 International License.