This work is licensed under a Creative Commons Attribution 4.0 International License.
V-I
General Information
DRACP ID DRACP01984
Peptide Name V-I
Sequence VIIKKIIKKIIKKI
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=15 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 7% Hemolysis=300 µM; Human erythrocytes: 12% Hemolysis=500 µM
Normal (non-cancerous) Cytotoxicity Human chondrocytes-articular cells Hca: 25% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C83H160N20O15
Absent amino acids ACDEFGHLMNPQRSTWY
Common amino acids I
Mass 191039
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 8
Net charge 6
Boman Index 518
Hydrophobicity 87.86
Aliphatic Index 215.71
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27644109
Title Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_14058
This work is licensed under a Creative Commons Attribution 4.0 International License.