This work is licensed under a Creative Commons Attribution 4.0 International License.
G-A
General Information
DRACP ID DRACP01985
Peptide Name G-A
Sequence GIIKKIIKKIIKKA
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50>40 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=300 µM; Human erythrocytes: 15% Hemolysis=500 µM
Normal (non-cancerous) Cytotoxicity Human chondrocytes-articular cells Hca: 25% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C77H148N20O15
Absent amino acids CDEFHLMNPQRSTVWY
Common amino acids IK
Mass 182623
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index -103
Hydrophobicity 35.71
Aliphatic Index 174.29
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27644109
Title Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_14059
This work is licensed under a Creative Commons Attribution 4.0 International License.