G-E

General Information


DRACP ID  DRACP01986

Peptide Name   G-E

Sequence  GIIKKIIKKIIKKE

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia Leukemia IC50>40 µM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: 0% Hemolysis=500 µM

Normal (non-cancerous) Cytotoxicity  Not active up to 40 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01986

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C79H150N20O17

Absent amino acids  ACDFHLMNPQRSTVWY

Common amino acids  IK

Mass  188426

Pl  11.1

Basic residues  6

Acidic residues  1

Hydrophobic residues  6

Net charge  5

Boman Index  -965

Hydrophobicity  -2.14

Aliphatic Index  167.14

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27644109

Title  Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity

Doi 10.1021/acsami.6b08297

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_14060

DRACP is developed by Dr.Zheng's team.