This work is licensed under a Creative Commons Attribution 4.0 International License.
General Information
DRACP ID DRACP01991
Peptide Name
Sequence DLFKQLQRLFLGILYCLYKIW
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=47±4 µM | Not available | Not available | 1 |
Hemolytic Activity Human erythrocytes：50% Hemolysis=132±16 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C132H201N29O28S
Absent amino acids AEHMNPSTV
Common amino acids L
Mass 303123
Pl 9.27
Basic residues 3
Acidic residues 1
Hydrophobic residues 11
Net charge 2
Boman Index 377
Hydrophobicity 62.86
Aliphatic Index 148.57
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 8480
Absorbance 280nm 424
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29679519
Title Designing Anticancer Peptides by Constructive Machine Learning
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_14293
This work is licensed under a Creative Commons Attribution 4.0 International License.