General Information


DRACP ID  DRACP01991

Peptide Name  

Sequence  DLFKQLQRLFLGILYCLYKIW

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma EC50=47±4 µM Not available Not available 1

Hemolytic Activity  Human erythrocytes:50% Hemolysis=132±16 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01991

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C132H201N29O28S

Absent amino acids  AEHMNPSTV

Common amino acids  L

Mass  303123

Pl  9.27

Basic residues  3

Acidic residues  1

Hydrophobic residues  11

Net charge  2

Boman Index  377

Hydrophobicity  62.86

Aliphatic Index  148.57

Half Life 
  Mammalian: 2.8 hour
  Yeast: 10 min
  E.coli: 2 min

Extinction Coefficient cystines  8480

Absorbance 280nm  424

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29679519

Title  Designing Anticancer Peptides by Constructive Machine Learning

Doi 10.1002/cmdc.201800204

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_14293

DRACP is developed by Dr.Zheng's team.