This work is licensed under a Creative Commons Attribution 4.0 International License.
General Information
DRACP ID DRACP01993
Peptide Name
Sequence RWNGRIIKGFYNLVKIWKDLKG
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=42±4 µM | Not available | Not available | 1 |
Hemolytic Activity Human erythrocytes：50% Hemolysis=89±6 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C129H202N36O28
Absent amino acids ACEHMPQST
Common amino acids K
Mass 308001
Pl 11.25
Basic residues 6
Acidic residues 1
Hydrophobic residues 9
Net charge 5
Boman Index -3508
Hydrophobicity -51.36
Aliphatic Index 101.82
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 12490
Absorbance 280nm 594.76
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29679519
Title Designing Anticancer Peptides by Constructive Machine Learning
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_14295
This work is licensed under a Creative Commons Attribution 4.0 International License.