This work is licensed under a Creative Commons Attribution 4.0 International License.
SOR-C27
General Information
DRACP ID DRACP02005
Peptide Name SOR-C27
Sequence EGKLSSNDTEGGLCKEFLHPSKVDLPR
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Blarina brevicauda
Type Native peptide
Classification
Active ACP TRPV6 antagonists Active ACP TRPV6 antagonists Active ACP TRPV6 antagonists
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | ~95%Inhibition=100 µM | Promega CellTiter Blue assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism SOR-C13 and SOR-C27, derived from the C-terminus of soricidin, are high-affinity antagonists of human TRPV6 channels that are up-regulated in a number of cancers
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H206N36O43S
Absent amino acids AIMQWY
Common amino acids L
Mass 342124
Pl 5.65
Basic residues 5
Acidic residues 5
Hydrophobic residues 6
Net charge 0
Boman Index -6271
Hydrophobicity -85.93
Aliphatic Index 68.52
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23554944
Title In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin
Doi 10.1371/journal.pone.0058866
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.