This work is licensed under a Creative Commons Attribution 4.0 International License.
SOR-C13
General Information
DRACP ID DRACP02006
Peptide Name SOR-C13
Sequence KEFLHPSKVDLPR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Blarina brevicauda
Type Native peptide
Classification
Active ACP TRPV6 antagonists
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | ~18%Inhibition=100 µM | Promega CellTiter Blue assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism SOR-C13 and SOR-C27, derived from the C-terminus of soricidin, are high-affinity antagonists of human TRPV6 channels that are up-regulated in a number of cancers
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C72H116N20O19
Absent amino acids ACGIMNQTWY
Common amino acids KLP
Mass 178005
Pl 9.54
Basic residues 4
Acidic residues 2
Hydrophobic residues 4
Net charge 2
Boman Index -3275
Hydrophobicity -91.54
Aliphatic Index 82.31
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23554944
Title In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin
Doi 10.1371/journal.pone.0058866
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.