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CCP-Ts sub peptide (14-39)
General Information
DRACP ID DRACP02007
Peptide Name CCP-Ts sub peptide (14-39)
Sequence NEPCDSDGDCCTSSEQCISTGSKYFC
Sequence Length 26
UniProt ID P0DM29
PubChem CID Not available
Origin Tityus serrulatus
Type Native peptide
Classification
Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| DU145 | Prostate carcinoma | Carcinoma | Sub peptide was internalized and directed to the intranuclear region. | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HUV-EC-C, HFF-1, MCR-5, HEK-293, BHK-21, MDCK: sub peptide was unable to cross the cell membrane
Target Not available
Affinity Not available
Mechanism As a drug delivery system targeting cancer cell nucleus using CPP-Ts’s nuclear-targeting property.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C108H163N29O47S5
Absent amino acids AHLMRVW
Common amino acids CS
Mass 322605
Pl 3.61
Basic residues 1
Acidic residues 5
Hydrophobic residues 2
Net charge -4
Boman Index -6361
Hydrophobicity -68.08
Aliphatic Index 15
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1740
Absorbance 280nm 69.6
Polar residues 16
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30282983
Title CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells
Doi 10.1038/s41598-018-33133-3
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.