HAL-2
General Information
DRACP ID DRACP02009
Peptide Name HAL-2
Sequence GKWMSLLKHILK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Halictines and their analogs
Type Native peptide
Classification
Active ACP
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=12±1 µM | MTT assay | 48 h | 1 |
SW480 | Colon adenocarcinoma | Carcinoma | IC50=35±3 µM | MTT assay | 48 h | 1 |
CCRF-CEM | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=34 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Rat erythrocytes: IC50=78.1 μM
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=23±9 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H116N18O14S
Absent amino acids ACDEFNPQRTVY
Common amino acids KL
Mass 165025
Pl 11.1
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index 59
Hydrophobicity 6.67
Aliphatic Index 130
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22100226
Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Doi 10.1016/j.peptides.2011.11.002
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available