This work is licensed under a Creative Commons Attribution 4.0 International License.
HAL-1/6
General Information
DRACP ID DRACP02021
Peptide Name HAL-1/6
Sequence GMWSKILGHLIk
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=15±1 µM | MTT assay | 48 h | 1 |
| SW480 | Colon adenocarcinoma | Carcinoma | IC50> 100 µM | MTT assay | 48 h | 1 |
| CCRF-CEM | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | Not available | MTT assay | 48 h | 1 |
Hemolytic Activity Rat erythrocytes: IC50=132 μM
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=≥40 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral Mix
Physicochemical Information
Formula C59H93N15O12S
Absent amino acids ACDEFNPQRTVY
Common amino acids GIL
Mass 143294
Pl 9.7
Basic residues 2
Acidic residues 0
Hydrophobic residues 5
Net charge 2
Boman Index 1263
Hydrophobicity 74.17
Aliphatic Index 130
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22100226
Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Doi 10.1016/j.peptides.2011.11.002
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.