Peptide Libraray

HAL-1

General Information

DRACP ID DRACP02022

Peptide Name HAL-1

Sequence GMWSKILGHLIR

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Halictines and their analogs

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=11±2 µM	MTT assay	48 h	1
SW480	Colon adenocarcinoma	Carcinoma	IC50=44±8 µM	MTT assay	48 h	1
CCRF-CEM	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Leukemia	IC50=49±9 µM	MTT assay	48 h	1

Hemolytic Activity Rat erythrocytes: IC50=82 μM

Normal (non-cancerous) Cytotoxicity HUVEC: IC50=48±19 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP02022

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C65H107N19O14S

Absent amino acids ACDEFNPQTVY

Common amino acids GIL

Mass 160714

Pl 11.65

Basic residues 3

Acidic residues 0

Hydrophobic residues 5

Net charge 3

Boman Index -229

Hydrophobicity 36.67

Aliphatic Index 130

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 500

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22100226

Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells

Doi 10.1016/j.peptides.2011.11.002

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available