This work is licensed under a Creative Commons Attribution 4.0 International License.
Tritrp DiSu
General Information
DRACP ID DRACP02028
Peptide Name Tritrp DiSu
Sequence CVRRFPWWYPFLRRC
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin porcine cathelicidin peptide
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=12.3 µM | MTT assay | 24h | 1 |
Hemolytic Activity RBC: IC50=20.9 µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50=26.2 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys15
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C100H141N29O17S2
Absent amino acids ADEGHIKMNQST
Common amino acids R
Mass 233540
Pl 11
Basic residues 4
Acidic residues 0
Hydrophobic residues 6
Net charge 4
Boman Index -3768
Hydrophobicity -38
Aliphatic Index 45.33
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 12615
Absorbance 280nm 901.07
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32126228
Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Doi 10.1016/j.bbamem.2020.183228
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.