This work is licensed under a Creative Commons Attribution 4.0 International License.
MPG
General Information
DRACP ID DRACP02030
Peptide Name MPG
Sequence GALFLGFLGAAGSTMGAWSQPKKKRKV
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin porcine cathelicidin peptide
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=15.8 µM | MTT assay | 24h | 1 |
Hemolytic Activity RBC: IC50 ≥ 65 µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50 ≥ 65 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Cysteamidation
Other Modification None
Chiral L
Physicochemical Information
Formula C129H208N36O32S
Absent amino acids CDEHINY
Common amino acids G
Mass 327130
Pl 12
Basic residues 5
Acidic residues 0
Hydrophobic residues 11
Net charge 5
Boman Index -1065
Hydrophobicity -0.37
Aliphatic Index 68.89
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 211.54
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32126228
Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Doi 10.1016/j.bbamem.2020.183228
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.