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EP5, Antimicrobial peptide OEP3121
General Information
DRACP ID DRACP02037
Peptide Name EP5, Antimicrobial peptide OEP3121
Sequence ACSAG
Sequence Length 5
UniProt ID P84182
PubChem CID Not available
Origin Eisenia fetida (Red wiggler worm)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 60.20% apoptotic=1.5 mg/mL; 48.12% apoptotic=0.75 mg/mL | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Mechanisms of EP5 may be directed to enter into cells to influence duplication and synthesis. Another mechanism was to form multimers by the connection of disulfide bonds with cysteins, also to make a hole in the cell membrane and induce the contents out of the cell.
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C14H25N5O7S
Absent amino acids DEFHIKLMNPQRTVWY
Common amino acids A
Mass 47898
Pl 5.92
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 244
Hydrophobicity 98
Aliphatic Index 40
Half Life
Mammalian: 1.4 hour
Yeast: 3 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title A novel antimicrobial vermipeptide family from earthworm Eisenia fetida
Doi 10.1016/j.ejsobi.2007.08.048
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
CancerPPD ID 4429
DBAASP ID DBAASPR_4320
This work is licensed under a Creative Commons Attribution 4.0 International License.