PTPRJ pep-19

General Information


DRACP ID  DRACP02039

Peptide Name   PTPRJ pep-19

Sequence  CHHNLTHAC

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Cancer targeted peptides PTPRJ agonist



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma 4.5 ± 0.1.4% Inhibition=160 μM Trypan blue assay 48 h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma 19 ± 2.82% Inhibition=160 μM Trypan blue assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  PTPRJ

Affinity  Not available

Mechanism  PTPRJ is a receptor-type protein tyrosine phosphatase whose expression is strongly reduced in the majority of investigated cancer cell lines and tumor specimens.It showed tumor suppressor activity in several models.

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02039

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys1<--->Cys9

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C41H62N16O12S2

Absent amino acids  DEFGIKMPQRSVWY

Common amino acids  H

Mass  117806

Pl  7.52

Basic residues  3

Acidic residues  0

Hydrophobic residues  2

Net charge  3

Boman Index  -1390

Hydrophobicity  -35.56

Aliphatic Index  54.44

Half Life 
  Mammalian: 5.5 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  15.63

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23627474

Title  Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation

Doi 10.1021/cb3007192

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




CancerPPD ID  3140

CancerPPD ID  3141

CancerPPD ID  3142

DRACP is developed by Dr.Zheng's team.