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PTPRJ pep-19.2
General Information
DRACP ID DRACP02041
Peptide Name PTPRJ pep-19.2
Sequence CAHNLTHAC
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from PTPRJ pep-19)
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides PTPRJ agonist
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 16.5 ± 2.12% Inhibition=160 μM | Trypan blue assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 30 ± 2.82% Inhibition=160 μM | Trypan blue assay | 48 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 32.0 ± 4.2% Inhibition=160 μM | Trypan blue assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target PTPRJ
Affinity Not available
Mechanism PTPRJ is a receptor-type protein tyrosine phosphatase whose expression is strongly reduced in the majority of investigated cancer cell lines and tumor specimens.It showed tumor suppressor activity in several models.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys9
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C38H60N14O12S2
Absent amino acids DEFGIKMPQRSVWY
Common amino acids ACH
Mass 111200
Pl 7.42
Basic residues 2
Acidic residues 0
Hydrophobic residues 3
Net charge 2
Boman Index -743
Hydrophobicity 20
Aliphatic Index 65.56
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 15.63
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23627474
Title Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.