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Bac
General Information
DRACP ID DRACP02051
Peptide Name Bac
Sequence RLCRIVVIRVCR
Sequence Length 12
PubChem CID Not available
Origin Bos taurus##Bos mutus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse macrophage leukemia cell | Leukemia | <20% Killing=400 µg/ml | MTT assay | 2 days | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=400 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys11
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C63H120N24O13S2
Absent amino acids ADEFGHKMNPQSTWY
Common amino acids R
Mass 168231
Pl 12.02
Basic residues 4
Acidic residues 0
Hydrophobic residues 6
Net charge 4
Boman Index -3024
Hydrophobicity 103.33
Aliphatic Index 170
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 11.36
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23109411
Title Linear bactenecin analogs with cell selectivity and anti-endotoxic activity
Doi 10.1002/psc.2460
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_13529
This work is licensed under a Creative Commons Attribution 4.0 International License.