This work is licensed under a Creative Commons Attribution 4.0 International License.
Bac-KKW
General Information
DRACP ID DRACP02055
Peptide Name Bac-KKW
Sequence KLKKIWWIKVKK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse macrophage leukemia cell | Leukemia | <20% Killing=400 µg/ml | MTT assay | 2 days | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=400 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C81H136N20O13
Absent amino acids ACDEFGHMNPQRSTY
Common amino acids K
Mass 179449
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -984
Hydrophobicity -68.33
Aliphatic Index 121.67
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 1000
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23109411
Title Linear bactenecin analogs with cell selectivity and anti-endotoxic activity
Doi 10.1002/psc.2460
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13532
This work is licensed under a Creative Commons Attribution 4.0 International License.