This work is licensed under a Creative Commons Attribution 4.0 International License.
Clavanin A
General Information
DRACP ID DRACP02065
Peptide Name Clavanin A
Sequence VFQFLGKIIHHVGNFVHGFSHVF
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Styela clava
Type Native peptide
Classification
Active ACP Immune system stimulating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse macrophage leukemia cell | Leukemia | LC50 >600 µM (35% cell death at 600 µM) | MTT assay | 48 h | 1 |
Hemolytic Activity Mouse erythrocytes: <10% Hemolysis=200 µM
Normal (non-cancerous) Cytotoxicity Mouse fibroblasts L929: LC50>600 µM (35% cell death at 600 µM); HEK293: LC50>600 µM (40% cell death at 600 µM)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Coordination bond: Val1<---Zn2+--->His17; Val1<---Zn2+--->His21
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C131H184N34O27
Absent amino acids ACDEMPRTWY
Common amino acids F
Mass 305971
Pl 9.71
Basic residues 5
Acidic residues 0
Hydrophobic residues 12
Net charge 5
Boman Index 887
Hydrophobicity 77.83
Aliphatic Index 101.3
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27804992
Title An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_2002
This work is licensed under a Creative Commons Attribution 4.0 International License.