This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1DRa
General Information
DRACP ID DRACP02067
Peptide Name Temporin-1DRa
Sequence HFLGTLVNLAKKIL
Sequence Length 14
UniProt ID M9NXM1
PubChem CID Not available
Origin Rana draytonii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=45 µM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=65 µM
Normal (non-cancerous) Cytotoxicity Mouse fibroblasts L929: LC50=18 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=AIB (Aminoisobutyric acid)
Chiral L
Physicochemical Information
Formula C75H127N19O17
Absent amino acids CDEMPQRSWY
Common amino acids L
Mass 179903
Pl 10.81
Basic residues 3
Acidic residues 0
Hydrophobic residues 8
Net charge 3
Boman Index 940
Hydrophobicity 92.14
Aliphatic Index 167.14
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17767978
Title Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa
Doi 10.1016/j.peptides.2007.07.023
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_2335
This work is licensed under a Creative Commons Attribution 4.0 International License.