This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1DRa [Aib4]
General Information
DRACP ID DRACP02071
Peptide Name Temporin-1DRa [Aib4]
Sequence HFLXTLVNLAKKIL
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Temporin-1DRa)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=25 µM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=25 µM
Normal (non-cancerous) Cytotoxicity Mouse fibroblasts L929: LC50=9 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=AIB (Aminoisobutyric acid)
Chiral L
Physicochemical Information
Formula C73H122N18O15
Absent amino acids CDEGMPQRSWY
Common amino acids L
Mass 183396
Pl 10.81
Basic residues 3
Acidic residues 0
Hydrophobic residues 8
Net charge 3
Boman Index 846
Hydrophobicity 95
Aliphatic Index 167.14
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17767978
Title Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa
Doi 10.1016/j.peptides.2007.07.023
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_2339
This work is licensed under a Creative Commons Attribution 4.0 International License.