Temporin-1DRa [Aib7]

General Information


DRACP ID  DRACP02074

Peptide Name   Temporin-1DRa [Aib7]

Sequence  HFLGTLXNLAKKIL

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (Derived from Temporin-1DRa)

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma LC50=22 µM CytoTox 96 non-radiactive cytotoxicity assay  1 h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis=22 µM

Normal (non-cancerous) Cytotoxicity  Mouse fibroblasts L929: LC50=13 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=AIB (Aminoisobutyric acid)

Chiral  L



Physicochemical Information


Formula  C70H116N18O15

Absent amino acids  CDEMPQRSVWY

Common amino acids  L

Mass  179188

Pl  10.81

Basic residues  3

Acidic residues  0

Hydrophobic residues  7

Net charge  3

Boman Index  536

Hydrophobicity  62.14

Aliphatic Index  146.43

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17767978

Title  Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa

Doi 10.1016/j.peptides.2007.07.023

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_2342

DRACP is developed by Dr.Zheng's team.