This work is licensed under a Creative Commons Attribution 4.0 International License.
GW-M1
General Information
DRACP ID DRACP02081
Peptide Name GW-M1
Sequence GANAAKKLATFAKKIFTAYW
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| AGS | Gastric adenocarcinoma | Carcinoma | IC50=46 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>500 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C106H162N26O25
Absent amino acids CDEHMPQRSV
Common amino acids A
Mass 253971
Pl 10.87
Basic residues 4
Acidic residues 0
Hydrophobic residues 11
Net charge 4
Boman Index -419
Hydrophobicity 8
Aliphatic Index 69
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 367.89
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25380626
Title Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.