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Piscidin 3
General Information
DRACP ID DRACP02085
Peptide Name Piscidin 3
Sequence FIHHIFRGIVHAGRSIGRFLTG
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Morone saxatilis (Striped bass) (Perca saxatilis)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HT-1080 | Fibrosarcoma | Sarcoma | IC50=26.01 µM | MTT/MTS assay | 24 h, 48 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=17.5 µM | MTT/MTS assay | 24 h, 48 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=21.6 µM | MTT/MTS assay | 24 h, 48 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=18.1 µM | MTT/MTS assay | 24 h, 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal; Antiviral; Anti-Inflammatory
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C116H179N37O25
Absent amino acids CDEKMNPQWY
Common amino acids GI
Mass 286669
Pl 12.8
Basic residues 6
Acidic residues 0
Hydrophobic residues 10
Net charge 6
Boman Index -2156
Hydrophobicity 45.45
Aliphatic Index 106.36
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34135370
Title Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption
Doi 10.1038/s41598-021-91670-w
Year 2021
Literature 2
Pubmed ID 31354312
Title Substitution of lysine for isoleucine at the center of the nonpolar face of the antimicrobial peptide, piscidin-1, leads to an increase in the rapidity of bactericidal activity and a reduction in toxicity
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.