This work is licensed under a Creative Commons Attribution 4.0 International License.
Alyteserin-2a [N15k]
General Information
DRACP ID DRACP02095
Peptide Name Alyteserin-2a [N15k]
Sequence ILGKLLSTAAGLLSkL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Alyteserin-2a)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=75 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=80 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=125 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | LC50=90 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=310 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification k=D-Lys
Chiral Mix
Physicochemical Information
Formula C68H122N16O18
Absent amino acids CDEFHMNPQRVWY
Common amino acids L
Mass 171957
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 9
Net charge 1
Boman Index 2502
Hydrophobicity 149.38
Aliphatic Index 183.13
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22965637
Title Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4373
This work is licensed under a Creative Commons Attribution 4.0 International License.