This work is licensed under a Creative Commons Attribution 4.0 International License.
Alyteserin-2a [A10W, N15K]
General Information
DRACP ID DRACP02104
Peptide Name Alyteserin-2a [A10W, N15K]
Sequence ILGKLLSTAWGLLSKL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Alyteserin-2a)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=6 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=6 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C82H141N19O20
Absent amino acids CDEFHMNPQRVY
Common amino acids L
Mass 198089
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 9
Net charge 2
Boman Index 1999
Hydrophobicity 108.13
Aliphatic Index 176.88
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 366.67
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22965637
Title Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4370
This work is licensed under a Creative Commons Attribution 4.0 International License.