BPC154

General Information


DRACP ID  DRACP02150

Peptide Name   BPC154

Sequence  KLLKLFKKKQ

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Induce apoptosis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma Carcinoma 28 ± 0.05% Growth inhibition=40 μM MTT assay 48 h 1

Hemolytic Activity  Human erythrocytes: 11 ± 1.7% Hemolysis=375 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02150

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Lys1<--->Gln10

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C62H112N16O12

Absent amino acids  ACDEGHIMNPRSTVWY

Common amino acids  K

Mass  143439

Pl  11.4

Basic residues  5

Acidic residues  0

Hydrophobic residues  4

Net charge  5

Boman Index  -1555

Hydrophobicity  -88

Aliphatic Index  117

Half Life 
  Mammalian: 5.5 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20708052

Title  Antimicrobial cyclic decapeptides with anticancer activity

Doi 10.1016/j.peptides.2010.07.027

Year  2010

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_3037

DRACP is developed by Dr.Zheng's team.