This work is licensed under a Creative Commons Attribution 4.0 International License.
BPC192
General Information
DRACP ID DRACP02167
Peptide Name BPC192
Sequence LKLLKFKKLQ
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | 20 ± 0.05% Growth inhibition=40 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 49 ± 7.7% Hemolysis=375 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Leu1<--->Gln10
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C62H111N15O12
Absent amino acids ACDEGHIMNPRSTVWY
Common amino acids KL
Mass 141938
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -508
Hydrophobicity -11
Aliphatic Index 156
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20708052
Title Antimicrobial cyclic decapeptides with anticancer activity
Doi 10.1016/j.peptides.2010.07.027
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3061
This work is licensed under a Creative Commons Attribution 4.0 International License.