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PMAP-23, Myeloid antibacterial peptide 23
General Information
DRACP ID DRACP02174
Peptide Name PMAP-23, Myeloid antibacterial peptide 23
Sequence RIIDLLWRVRRPQKPKFVTVWVR
Sequence Length 23
UniProt ID P49930
PubChem CID 16130705
Origin Sus scrofa
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=35 µM | MTT assay | 3 days | 1 |
| SNU-601 | Gastric signet ring cell adenocarcinoma | Carcinoma | IC50=47 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 4.8% Hemolysis=100 µM
Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: 25% Killing=100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C140H229N43O28
Absent amino acids ACEGHMNSY
Common amino acids R
Mass 335521
Pl 12.69
Basic residues 7
Acidic residues 1
Hydrophobic residues 11
Net charge 6
Boman Index -5905
Hydrophobicity -29.57
Aliphatic Index 118.26
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 11000
Absorbance 280nm 500
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12054589
Title Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid
Doi 10.1016/S0006-291X(02)00222-X
Year 2002
Literature 2
Pubmed ID 20512598
Title C-terminal amidation of PMAP-23: translocation to the inner membrane of Gram-negative bacteria
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3050
This work is licensed under a Creative Commons Attribution 4.0 International License.