This work is licensed under a Creative Commons Attribution 4.0 International License.
PMAP-23 [Q13W]
General Information
DRACP ID DRACP02176
Peptide Name PMAP-23 [Q13W]
Sequence RIIDLLWRVRRPWKPKFVTVWVR
Sequence Length 23
UniProt ID P49930
PubChem CID 16129743
Origin Synthetic (Derived from PMAP-23)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=20 µM | MTT assay | 3 days | 1 |
| SNU-601 | Gastric signet ring cell adenocarcinoma | Carcinoma | IC50=30 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C146H231N43O27
Absent amino acids ACEGHMNQSY
Common amino acids R
Mass 341329
Pl 12.69
Basic residues 7
Acidic residues 1
Hydrophobic residues 12
Net charge 6
Boman Index -5118
Hydrophobicity -18.26
Aliphatic Index 118.26
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 750
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12054589
Title Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid
Doi 10.1016/S0006-291X(02)00222-X
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3052
This work is licensed under a Creative Commons Attribution 4.0 International License.