Peptide Libraray

PMAP-23 [R10W][Q13W][K14W]

General Information

DRACP ID DRACP02180

Peptide Name PMAP-23 [R10W][Q13W][K14W]

Sequence RIIDLLWRVWRPWWPKFVTVWVR

Sequence Length 23

UniProt ID P49930

PubChem CID Not available

Origin Synthetic (Derived from PMAP-23)

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Leukemia	IC50=11 µM	MTT assay	3 days	1
SNU-601	Gastric signet ring cell adenocarcinoma	Carcinoma	IC50=10 µM	MTT assay	3 days	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP02180

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C156H227N41O27

Absent amino acids ACEGHMNQSY

Common amino acids W

Mass 350136

Pl 12.51

Basic residues 5

Acidic residues 1

Hydrophobic residues 14

Net charge 4

Boman Index -2605

Hydrophobicity 10.43

Aliphatic Index 118.26

Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min

Extinction Coefficient cystines 27500

Absorbance 280nm 1250

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 12054589

Title Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid

Doi 10.1016/S0006-291X(02)00222-X

Year 2002

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_3056