This work is licensed under a Creative Commons Attribution 4.0 International License.
CRAMP-18[E2K]
General Information
DRACP ID DRACP02182
Peptide Name CRAMP-18[E2K]
Sequence GKKLKKIGQKIKNFFQKL
Sequence Length 18
UniProt ID P51437
PubChem CID Not available
Origin Synthetic (Derived from CRAMP-18)
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=25 µM | MTT assay | 3 days | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=34 µM | MTT assay | 3 days | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=20 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: Not active up to 100 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C102H176N28O22
Absent amino acids ACDEHMPRSTVWY
Common amino acids K
Mass 245011
Pl 11.58
Basic residues 7
Acidic residues 0
Hydrophobic residues 6
Net charge 7
Boman Index -2905
Hydrophobicity -91.11
Aliphatic Index 86.67
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10973820
Title CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3074
This work is licensed under a Creative Commons Attribution 4.0 International License.