CRAMP-18[Q16K]

General Information


DRACP ID  DRACP02185

Peptide Name   CRAMP-18[Q16K]

Sequence  GEKLKKIGQKIKNFFKKL

Sequence Length  18

UniProt ID  P51437 

PubChem CID  Not available

Origin  Synthetic (Derived from CRAMP-18)

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50>100 µM MTT assay 3 days 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia Leukemia IC50>100 µM MTT assay 3 days 1
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia Leukemia IC50>100 µM MTT assay 3 days 1

Hemolytic Activity  Human erythrocytes: 0.2% Hemolysis=100 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02185

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C102H175N27O23

Absent amino acids  ACDHMPRSTVWY

Common amino acids  K

Mass  245109

Pl  11.2

Basic residues  7

Acidic residues  1

Hydrophobic residues  6

Net charge  6

Boman Index  -3032

Hydrophobicity  -91.11

Aliphatic Index  86.67

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 10973820

Title  CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity

Doi 10.1006/bbrc.2000.3269

Year  2000

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_3077

DRACP is developed by Dr.Zheng's team.