This work is licensed under a Creative Commons Attribution 4.0 International License.
Anoplin
General Information
DRACP ID DRACP02186
Peptide Name Anoplin
Sequence GLLKRIKTLL
Sequence Length 10
UniProt ID P0C005
PubChem CID 10307332
Origin Anoplius samariensis
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>256 µM | MTT assay | 1 h | 1 |
Hemolytic Activity Mouse erythrocytes: 10% Hemolysis>256 µM
Normal (non-cancerous) Cytotoxicity HEK293T: IC50>256 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C54H103N15O12
Absent amino acids ACDEFHMNPQSVWY
Common amino acids L
Mass 131523
Pl 11.82
Basic residues 3
Acidic residues 0
Hydrophobic residues 5
Net charge 3
Boman Index -305
Hydrophobicity 63
Aliphatic Index 195
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31676352
Title Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria
Doi 10.1016/j.ejps.2019.105123
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3116
This work is licensed under a Creative Commons Attribution 4.0 International License.