This work is licensed under a Creative Commons Attribution 4.0 International License.
Ano-D4,7–4C12
General Information
DRACP ID DRACP02191
Peptide Name Ano-D4,7–4C12
Sequence GLLXRIkTLL
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Anoplin)
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=16 µM | MTT assay | 1 h | 1 |
Hemolytic Activity Mouse erythrocytes: 10% Hemolysis=32 µM
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=32 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=D-Lys-C12 (D-Lysine with laurylated side group); k=D-Lys
Chiral Mix
Physicochemical Information
Formula C42H75N11O8
Absent amino acids ACDEFHKMNPQSVWY
Common amino acids L
Mass 113285
Pl 10.55
Basic residues 1
Acidic residues 0
Hydrophobic residues 5
Net charge 1
Boman Index 805
Hydrophobicity 141
Aliphatic Index 195
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31676352
Title Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria
Doi 10.1016/j.ejps.2019.105123
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.